Antiglycoprotein VI SCFV fragment for the treatment of thrombosis

• 收藏
• 分享

专利权人:

アンスティテュ、ナショナル、ド、ラ、サント、エ、ド、ラ、ルシェルシュ、メディカル（アンセルム）;アンスティテュ、ナショナル、ド、ラ、サント、エ、ド、ラ、ルシェルシュ、メディカル(アンセルム)

发明人:

マルティーヌ、ジャンロ‐ペル,フィリップ、ビリアル,ジュリアン、ムザル

申请号：

JP2009533871

公开号：

JP5501765B2

申请日:

2007.10.26

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to a single chain variable fragment (scFv 9012.2) directed against human glycoprotein VI, constituted of the VH and VL domains of 9012.2.2 monoclonal antibody linked via a (Gly 4 Ser) 3 peptide and followed by a "c-myc" flag, represented by SEQ ID NO:1. The invention also concerns functional variants of said scFv 9012.2 fragment with identical heavy and light chains complementary determining regions 1, 2 and 3, and preferably humanized functional variants such as the humanized scFv fragment represented by SEQ ID NO:28. The invention also relates to nucleic acids encoding such a scFv fragment, expression vectors and host cells to produce such a scFv fragment, as well as therapeutic uses of such a scFv fragment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/