ROTHER, RUSSELL P.,SHERIDAN, DOUGLAS L.,TAMBURINI, PAUL P.,ZHANG, YUCHUN
申请号：
ES11775670
公开号：
ES2552954T3
申请日:
2011.04.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
An isolated antibody or antigen-binding fragment thereof that binds to a free C5a polypeptide, wherein the free C5a is a human polypeptide (C5ah) having the amino acid sequence depicted in SEQ ID NO: 1, and in the that the antibody or antigen-binding fragment thereof binds to the free C5ah polypeptide in vitro with a KD that is less than 1.25 x 10-9 M as measured by surface plasmon resonance (RPS) in the presence of an excess C5 molar of a non-cleaved natural human being, and wherein the antibody or antigen-binding fragment thereof comprises: I. (a) a light chain polypeptide comprising: (i) a light chain CDR1 comprising the sequence of amino acids represented in SEQ ID NO: 20； a light chain CDR2 comprising the amino acid sequence depicted in SEQ ID NO: 21； and a light chain CDR3 comprising the amino acid sequence depicted in SEQ ID NO: 22； or (ii) a light chain CDR1 comprising the amino acid sequence depicted in SEQ ID NO: 20； a light chain CDR2 comprising the amino acid sequence depicted in SEQ ID NO: 38； and a light chain CDR3 comprising the amino acid sequence depicted in SEQ ID NO: 22； and (b) a heavy chain polypeptide comprising: (i) a heavy chain CDR1 comprising the amino acid sequence depicted in SEQ ID NO: 28； a heavy chain CDR2 comprising the amino acid sequence depicted in SEQ ID NO: 29； and a heavy chain CDR3 comprising the amino acid sequence depicted in SEQ ID NO: 30； or (ii) a heavy chain CDR1 comprising the amino acid sequence depicted in SEQ ID NO: 28； a heavy chain CDR2 comprising the amino acid sequence depicted in SEQ ID NO: 46； and a heavy chain CDR3 comprising the amino acid sequence depicted in SEQ ID NO: 47； II. (a) a light chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 37 and a heavy chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 27； (b) a light chain polypeptide comprising the amino acid sequence depicted SEQ ID NO: 36 a heavy chain polypeptide comprising the amino acid sequence depic
