The present invention relates to a peritoneal dialysis fluid comprising a compound inhibiting glycogen synthase kinase (GSK)-3 activity, in particular (GSK)-3β activity, for use in the prevention of infectious and non-infectious peritoneal complications such as peritonitis, peritoneal membrane injury, damage and failure, barrier dysfunction and mesothelial cell detachment.本發明係關於一種腹膜透析液，其包含抑制肝糖合成酶激酶-3(glycogen synthase kinase-3，GSK-3)活性之化合物，特別是，抑制GSK-3β活性之化合物。此化合物用於預防傳染性及非傳染性腹膜併發症，諸如腹膜炎，腹膜損傷、損壞及破壞，屏障功能障礙(barrier dysfunction)及間皮細胞剝離(mesothelial cell detachment)。
