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Substituted tricyclic heterocycles as histamine 4 receptor inhibitors
- 专利权人:
- Jung Sook Kim;Hye Jung Kim;Sun Young Han;Sung Oh Ahn;Dong Oh Yoon;Pil Su Ho;Won Il Lee;Woul Seong Park
- 发明人:
- Pil Su Ho,Dong Oh Yoon,Sun Young Han,Won Il Lee,Jung Sook Kim,Woul Seong Park,Sung Oh Ahn,Hye Jung Kim
- 申请号：
- US14347950
- 公开号：
- US09586959B2
- 申请日:
- 2012.09.28
- 申请国别(地区):
- US
- 年份:
- 2017
- 代理人:
- 摘要：
- The present invention relates to novel heterocyclic compounds of formula 1 useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
