Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure. In an exemplary system for detecting a luminal organ response to mechanical stimulation of the present disclosure, the system comprises a first conduit having a proximal end, a distal end, and a lumen therethrough, the distal end sized and shaped to fit within a luminal organ, a pressure transducer, and at least one pressurized vessel capable of introducing a fluid into the lumen of the first conduit, wherein the first conduit, the pressure transducer, and the at least one pressurized vessel are either directly or indirectly coupled to one another so that a pressure of a fluid present within the first conduit can be measured using the pressure transducer.
