Quinazoline derivatives of the following formula:wherein R1, R2, R3, R4, R5, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.本發明是有關於如下結構式的喹唑啉衍生物:其中Ar、R1、R2、R3、R4、R5、X和Z在此有所定義。本發明還公開了一種用其中一種化合物治療腫瘤的方法。