Eljárás pirferint tartalmazó, nyújtott leadású tabletta formájában lévõ gyógyászati készítmény elõállítására, és a készítmény alkalmazása krónikus veseelégtelenség, mell tokzsugorodás, és májfibrózis visszaszorítására embernél
Armendariz Borunda, Juan,Magana Castro, Jose Augustin Rogelio,Cervantes Guadarrama, Jorge
申请号：
HUE15161929
公开号：
HUE036511T2
申请日:
2012.07.13
申请国别(地区):
HU
年份:
2018
代理人:
摘要：
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis； it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-± and anti-TGF-²1 action for the treatment of hepatic fibrosis.
