#$%^&*AU2012203787B220140710.pdf#####ABSTRACT Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a 5 delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.FIGURE 1 Dissolution of Encapsulated Combination to Two Different AT1001 Beads 120 100 80 40 20 0 15 30 45 60 75 90 105 120 135 150 165 180 195 Time (min)
