MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS

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专利权人:

Anastasia Khvorova

发明人:

Anastasia Khvorova,Annaleen Vermeulen,Rob Kaiser,Jon Karpilow,Nicolaas M.J. Vermeulen,Walt Mahoney

申请号：

US13490634

公开号：

US20120245219A1

申请日:

2012.06.07

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.

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中国工程科技知识中心

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