SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

GUNAGA, Prashantha,RICHTER, Jeremy,YADAV, Navnath Dnyanoba,PANDA, Manoranjan,GODESI, Sreenivasulu

申请号：

SG11201809173T

公开号：

SG11201809173TA

申请日:

2017.04.19

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N； Y is CR4 or N, provided that Y is N only if X is N； R1 is Formulae (A) or (B)； each W is independently NR1b or O； Z is a bond or CHR1d； and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

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http://www.ckcest.cn/home/