Provided herein are methods for treating sickle cell disease, comprising administering to a subject 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)-methoxy)benzaldehyde (Compound 1), or a polymorph thereof, in certain dosing regimens.本文提供了用於治療鐮形細胞疾病之方法,該等方法包括以某些劑量方案向受試者給予2-羥基-6-((2-(1-異丙基-1H-吡唑-5-基)吡啶-3-基)-甲氧基)苯甲醛(化合物1)或其多晶型物。