EMORY UNIVERSITY;CHILDRENS HEALTHCARE OF ATLANTA INC.
发明人:
MOORE, Martin, L. L,MENG, Jia,HOTARD, Anne,LITTAUER, Elizabeth,STOBART, Christopher,克裡斯多佛‧斯托巴特,馬丁‧,‧摩爾,佳‧孟,安妮‧霍泰德,伊麗莎白‧利陶爾
申请号：
HK16106371.8
公开号：
HK1218428A
申请日:
2016.06.03
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure relates to isolated or recombinant nucleic acids and polypeptides comprising desirable nucleic acid sequences and mutations disclosed herein. In certain embodiments, isolated or recombinant RSV comprising the nucleic acids and polypeptides disclosed herein (e.g., attenuated recombinant RSV) are also provided, as are immunogenic compositions including such nucleic acids, polypeptides, and RSV genomes that are suitable for use as vaccines. Attenuated or killed RSV containing these nucleic acids and mutation in the form of copied nucleic acids (e.g., cDNAs) are also contemplated.
