A water dispersible wipe includes a web including at least 10 weight % (wt. %) of a fibrillated regenerated cellulose microfiber (CMF) based on the total weight of the web, the remaining fibers of the web including natural cellulosic fibers; a wet strength agent disposed within the web; and a pH-modifying composition having a wetting pH disposed within the web; wherein the water dispersible wipe includes at least two webs and disperses upon exposure to an aqueous environment having a pH greater than the wetting pH and has a cross-direction (CD) wet tensile of at least 75 g/in after 24 hours as measured according to IVDA Standard Test WSP 110.4 (05).