To provide an angiopoietin-like factor 2(Angptl2) inhibitor.SOLUTION: An Angptl2 inhibitor has a compound having a specific chemical structure represented by formula (I) or a pharmaceutically acceptable salt thereof. There are also provided a cosmetic product, quasi drug, pharmaceutical, or food composition containing the inhibitor. [R-Rindependently represent H or the like].SELECTED DRAWING: Figure 4【課題】アンジオポエチン様因子２（Ａｎｇｐｔｌ２）阻害剤の提供。【解決手段】式（Ｉ）で代表される特定の化学構造を有する化合物又は薬学的に許容されるその塩からなる、Ａｎｇｐｔｌ２阻害剤。前記阻害剤を含む、化粧品、医薬部外品、医薬品、又は食品組成物。［Ｒ１～Ｒ７は、各々独立にＨ等］【選択図】図４
