Michele CARGILL,Olga IAKOUBOVA,James J. DEVLIN,Zenta TSUCHIHASHI,Peter SHAW,Lynn Marie PLOUGHMAN,Kim E. ZERBA,Koustubh RANADE,Todd KIRCHGESSNER
申请号：
US15894253
公开号：
US20180305762A1
申请日:
2018.02.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
