Described are silicone hydrogels with high levels of polyamides exhibiting an excellent balance of physical, mechanical, and biological properties. The silicone hydrogels are formed from a reactive monomer mixture comprising: a hydroxylalkyl (meth)acrylate monomer； hydroxyl-containing silicone components； and a polyamide, wherein the polyamide is present in an amount greater than 15 weight percent, based on the total weight of reactive components in the reactive monomer mixture.所述者係含有高含量之聚醯胺之聚矽氧水凝膠，其展現出物理、機械與生物性質的優異平衡。該等聚矽氧水凝膠係形成自反應性單體混合物，該反應性單體混合物包含：(甲基)丙烯酸羥烷酯單體；含羥基之聚矽氧組分；及聚醯胺，其中該聚醯胺之存在量係大於15重量百分比，此係基於該反應性單體混合物中之反應性組分的總重量。
