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Imidazoles with anti-inflammatory activity, a process for their Preparation and Pharmaceutical compositions containing them
专利权人:
PALAU PHARMA SA
发明人:
申请号:
NO2011012
公开号:
NO2011012I2
申请日:
2011.07.27
申请国别(地区):
NO
年份:
2013
代理人:
摘要:
Compounds of formula I wherein: one of X or Y represents N and the other represents C; R1 represents hydrogen, methyl, halogen, cyano, nitro, -CHO, -COCH3 or -COOR4; R2 represents optionally-substituted aryl or heteroaryl; R3 represents C1-8 alkyl, C1-8 haloalkyl or -NR4R6; R4 represents hydrogen, C1-8 alkyl or arylC0-8 alkyl; R6 represents hydrogen, C1-8 alkyl, arylC1-8 alkyl, -COR8 or -COOR8; R8 represents C1-8 alkyl or C1-8 haloalkyl; aryl in the above definitions represents phenyl or naphthyl; and heteroaryl in the above definitions represents pyridine, pyrazine, pyrimidine or pyridazine, which can be optionally fused to a benzene ring. These compounds are useful as cyclooxygenase-2 inhibitors. <;CHEM>;
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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