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ХИМЕРНЫЕ АНТИГЕНЫ ДЛЯ ВАКЦИНЫ ПРОТИВ ВИРУСА ГЕПАТИТА С
专利权人:
СЕНТРО ДЕ ИНХЕНЬЕРИЯ ХЕНЕТИКА И БИОТЕКНОЛОХИЯ (CU)
发明人:
ДУЭНЬЯС КАРРЕРА Сантьяго (CU),АГИЛАР НОРЬЕГА Дайлен (CU),АМАДОР КАНЬИСАРЕС Ялена (CU),АЛЬВАРЕС-ЛАХОНЧЕРЕ ПОНСЕ ДЕ ЛЕОН Лис (CU),МАРТИНЕС ДОНАТО Хильян (CU),ГОНСАЛЕС БЛАНКО Сонья (CU)
申请号:
RU2015121429
公开号:
RU2015121429A
申请日:
2013.10.28
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Chimeric vaccine antigen against hepatitis virus C (HCV), comprising a) a first segment consisting of the region E2 (amino acids 408-540) HCV polyprotein, b) a second segment consisting of a region E1 (amino acids 190-222) HCV polyprotein and c) a third segment consisting of a region Core (amino acids 1-50) of the protein, in that poryadke.2. Chimeric vaccine antigen according to claim. 1, wherein the amino acid sequence selected from the group consisting of SEQ ID No. 10 (Eq1 antigen) and SEQ ID No. 16 (Eq1b antigen) .3. Chimeric vaccine antigen according to claim. 1, in which its sequence further comprises at least one epitope-specific T-helper limfotsitov.4. Chimeric vaccine antigen according to claim. 3, wherein the epitope-specific T-helper lymphocyte epitope represents HCV.5 nonstructural proteins. Chimeric vaccine antigen according to claim. 4, wherein the protein is a nonstructural NS3.6. Chimeric vaccine antigen according to claim. 5, wherein the amino acid sequence is SEQ ID No. 14 (EqNS3 antigen) .7. Chimeric vaccine antigen according to claim. 3, wherein the epitope-specific T-helper lymphocytes, is an artificial epitop.8. Chimeric vaccine antigen according to claim. 7, wherein the artificial epitope is selected from the group consisting of epitope P1M (SEQ ID No. 17) epitope and P2B (SEQ ID No. 18) .9. Chimeric vaccine antigen according to claim. 8, wherein the amino acid sequence selected from the group consisting of SEQ ID No. 12 (antigen NSEq2), SEQ ID No. 13 (antigen EqNSb) and SEQ ID No. 15 (EqP1 antigen) .10. A vaccine composition comprising a chimeric antigen for vaccines against HCV which comprises a) a first segment consisting of the region E2 (amino acids 408-540) HCV polyprotein, b) a second segment consisting of a region E1 (amino acids 190-222) HCV polyprotein and c) a third segment consisting of a region Core (amino acids 1-50) HCV polyprotein, in that order and excipients1. Химерный антиген для вакцины против вируса гепатита C (HCV), с
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