Combined preparations for the treatment of cancer or infection

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专利权人:

Immutep S.A.S.

发明人:

Brignone, Chrystelle,Triebel, Frédéric

申请号：

AU2016205983

公开号：

AU2016205983A1

申请日:

2016.01.08

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Combined preparations, and pharmaceutical compositions, comprising: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules； and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, are described. The PD-1 pathway inhibitor, such as an anti-PD-1 antibody or an anti-PD-L1 antibody, and a soluble derivative of LAG- 3, acting as an APC activator, together synergistically activate T cells (in particular, CD8

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