ALLEN, JENNIFER R.,AMEGADZIE, ALBERT,BOURBEAU, MATTHEW P.,BROWN, JAMES A.,CHEN, JIAN J.,CHENG, YUAN,FROHN, MICHAEL J.,GUZMAN-PEREZ, ANGEL,HARRINGTON, PAUL E.,LIU, LONGBIN,LIU, QINGYIAN,LOW, JONATHAN D
申请号：
CA2957544
公开号：
CA2957544A1
申请日:
2015.08.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.
