TRAVERSO, Carlo Giovanni,ABRAMSON, Alex G.,SALVADOR, Ester Caffarel,ROXHED, Niclas,KHANG, Minsoo,BENSEL, Taylor,DELLAL, David,LANGER, Robert S.
申请号：
US2018033204
公开号：
WO2018213588A1
申请日:
2018.05.17
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).Dune manière générale, linvention concerne des articles à redressement automatique, tels que des capsules à redressement automatique, destinés à être administrés à un sujet. Dans certains modes de réalisation, larticle à redressement automatique peut être configuré de telle sorte que larticle peut sorienter par rapport à une surface (par exemple, une surface dun tissu dun sujet). Les articles à redressement automatique décrits ici peuvent compr
