This note refers to the ingredients, toolkits, uses, systems and methods for dealing with overweight and obesity, preferably a comprehensive weight control program combined with Internet and / or telephone management, preferably for people at risk. What's more serious is heart disease 1. Requirement 1: a method for treating patients most likely to suffer adverse cardiovascular consequences, characterized by:2. Overweight or obese: identify a obese or overweight patient who is most likely to suffer from adverse cardiovascular disease； And the main body of the effective treatment, so that it has sustained release of Nadine or a drug acceptable salts and sustained release of propyl bromide, or a drug acceptable salts. Claim 2: Method in accordance with claim 1,It is characterized by the fact that people who are considered overweight or obese (a) are most likely to suffer from adverse cardiovascular consequences if they are diagnosed with cardiovascular disease with at least one risk factor, Selected from the following groups: recorded myocardial infarction records, more than 3 months before confirmation； history of coronary retransplantation, including coronary artery transplantation； stent placement, Traumatic coronary angioplasty or laser capsulectomy； history of expensive or marginal chemotherapy,Even if it is hypertension, endocrinology, lower extremity myocardial obstruction resection, abdominal aneurysm repair, negative or epidemic myocardial infarction, ischemic vascular changes, ECG changes for skilled gymnastics test or just like heart research； Brain index of ankle and lt； 0.9% estimated by simple physical contact in the first two years of ankle and lt determination； and 50% of coronary, carotid or inferior arteries in the first two years of ankle, carotid or lower extremity determination； And / or (b) have a diagnosis of type 2 diabetes with at least 2 risk factors,Selected from the following groups: hypertension with or without pharmacological treatment； 14
