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DERIVES DE BENZIMIDAZOLE COMME INHIBITEURS DES BROMODOMAINES
专利权人:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
BIT, RINO ANTONIO,BROWN, JOHN ALEXANDER,HUMPHREYS, PHILIP G.,JONES, KATHERINE LOUISE
申请号:
CA2979504
公开号:
CA2979504A1
申请日:
2016.03.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
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中国工程科技知识中心
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