Claim 1: compound (1) represented by formula,(2)(3) Or (4),O acceptable table salt, in each case, n is independent of 0, 1, 2 or 3； in each case, M1 is independent of 1, 2 or 3； in each case, M2 is independent of 0, 1 or 2； in each case, M4 is independent of 0, 1 or 2； E each publication is independent of - C (r83044) 8322 -,-N (R) -o. S, s (o) and S (o) 832222；Each time r83044 appears, it will independently select the group composed of hydrogen, halogen CN and no832222；optionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₈ alkenyl, optionally substituted C₂₋₈ alkynyl, optionally substituted C₃₋₈ cycloalkyl, optionally substituted 3- to 8-membered heterocyclic ring, optionally substituted aryl, optionally substituted heteroaryl and -L¹ -R¹；There I am- yes.-No.-C (O) --That's it.-OC (o)..-C (O) N (R) --N (R) C (O) --OC (O) N (R) --N (R) C (O) O--N (R) C (O) N (R) --S (O) --S (O) --S (O) N (R) --N (R) S (O) -R¹ at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted C₁₋₆ alkyl, optionally substituted Cque alkenyl, optionally substituted C₂₋₈ alkynyl, optionally substituted C₃₋₈ cycloalkyl, 3- to 8-membered heterocyclic ring optionally substituted, optionally substituted aryl and optionally substituted heteroaryl； R¹¹ at each occurrence is independently selected from the group consisting of hydrogen, halogen, hydroxy, protected hydroxy, -CN, amino, protected amino, optionally substituted aryl, optionally substituted heteroaryl,optionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₈ alkenyl, optionally substituted C₂₋₈ alkynyl, optionally substituted C₃₋₈ cycloalkyl, optionally substituted 3- to 8-membered heterocyclic ring, optionally substituted C₁₋₆ alkoxy, -NH- optionally substituted C₁₋₆-alkyl, -N (C₁₋₆-alkyl) ₂,-CO₂H, -C (O) ₂-optionally substituted C₁₋₆-alkyl, -C (O) NH-optionally substituted C₁₋₆-alkyl and -C (O) -optionally substituted C₁₋₆-alkyl； R²¹ at each occurrence is independently selected
