YAN CHEN,ELENA GETAMANOVA,MARTIN C WRIGHT,ALHARRIS,AI CHING LIM,JOCHEM GOKEMEIJER,LIN SUN,MICHAEL WITTEKIND
申请号：
IN2338/DELNP/2011
公开号：
IN2011DN02338A
申请日:
2011.03.30
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
a) an 10Fn3 domain having from about 80 to about 150 amino acids, wherein at least one of the loops of said 10Fn3 domain participate in target binding and b) a covalently bound polyethylene glycol (PEG) moiety, wherein said Fn3 polypeptide binds to the target with a KD of less than 100 nM and has a clearance rate of less than 30 mL/hr/kg in a mammal.
