An image processing apparatus including a storage unit and a processing unit is provided. A group of first breast images captured through different capturing directions by X-ray is stored in the storage unit. A second breast image scanned by ultrasound is stored in the storage unit. The processing unit accesses and executes modules stored in the storage unit. The first and the second breast images are obtained by an image input module. On the group of the first breast images, a common first region of interest (ROI) is selected by a first selection module. Distance parameters and an azimuth parameter of the first ROI on each of the first breast images are calculated by a first calculation unit. Based on the distance parameters and the azimuth parameters, a position of the first ROI on the second breast image is determined through a cross-modality matching model by a first determination module.影像處理裝置,包括儲存單元與處理單元。儲存單元儲存以X光由不同的拍攝方向所拍攝的一組第一乳房影像、以超音波所掃描的第二乳房影像以及記錄多個模組。處理單元耦接儲存單元,且存取並執行儲存單元所記錄的模組。影像輸入模組取得該組的第一乳房影像與第二乳房影像。第一選取模組於該組的第一乳房影像上,選取共同的第一關注區域。第一計算模組計算第一關注區域在每一第一乳房影像的距離參數與方位參數。第一判斷模組透過跨模態對位模型,基於前述距離參數與前述方位參數,判斷第一關注區域在第二乳房影像中的位置。100‧‧‧影像處理裝置120‧‧‧處理單元140‧‧‧儲存單元142‧‧‧影像輸入模組144‧‧‧第一選取模組146‧‧‧第一計算模組148‧‧‧第一判斷模組150‧‧‧第一訓練模組