PROBLEM TO BE SOLVED: To provide a hollow fiber membrane module which has a seal structure capable of reliably sealing blood and suppressing residence of blood on an inner part of a header, and has no difficulty upon manufacture.SOLUTION: A separation membrane module 1 includes: a hollow fiber membrane bundle 5 a main body case 4 in which the hollow fiber membrane 5 is stored a diaphragm 6 which fixes the hollow fiber membrane bundle 5 to an inner wall of a main body case 4 end part and forms an end surface on the main body case 4 end part together with the hollow fiber membrane bundle 5 a cover material made of a thermoplastic resin having an inlet port or an outlet port of liquid to be treated attached to the main body case 4 end part. Therein, a ring member made of thermoplastic resin is provided on the main body case 4 end surface, at least a part of one surface of the ring member is liquid-tightly fixed to the diaphragm 6 and the inner surface of the cover material is liquid-tightly welded with the other one surface of the ring member.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2017,JPO&INPIT【課題】血液を確実にシールでき、かつ、ヘッダー内部における血液の滞留を抑制することが可能となるシール構造を有する、製造上の困難もない中空糸膜モジュールを提供する。【解決手段】中空糸膜束5と、中空糸膜束5が収納される本体ケース4と、中空糸膜束5を本体ケース4端部の内壁に固定し、中空糸膜束5とともに本体ケース4端部における端面を形成する隔壁6と、本体ケース4端部に取り付けられた、被処理液の導入口もしくは導出口を有する熱可塑性樹脂製蓋材と、を有する分離膜モジュール1において、本体ケース4端面には熱可塑性樹脂製リング部材を備え、リング部材の一面の少なくとも一部は前記隔壁6に液密に固定し、前記蓋材の内面と前記リング部材の他の一面とを液密に溶着する中空糸膜モジュール。【選択図】図2