ALLVIVO VASCULAR, INC.;THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY
发明人:
NEFF, JENNIFER A.,JOSHI, PRANAV R.,MCGUIRE, JOSEPH
申请号：
CA2696996
公开号：
CA2696996C
申请日:
2008.07.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention is based on the recognition that known antimicrobial compounds,such as nisin or other lantibiotics,can be made to form a long lasting antimicrobial surface coating by linkingthe peptide with a block polymer, such as PLURONIC?F108 or an end group activated polymer (EGAP) in a manner to form a flexibletether and/or entrap the peptide. The entrappedpep-tide provides antimicrobial action by early release from entrapment whilethe tethered peptide provides longer lasting antimicrobialprotection. Antimicrobial gels and foams may be prepared using theantimicrobial peptide containing block copolymers.
