Xiaoming Li;Curtis Thompson;Gregory I. Frost;Harold Michael Shepard
发明人:
Harold Michael Shepard,Curtis Thompson,Xiaoming Li,Gregory I. Frost
申请号：
US13135817
公开号：
US20120020951A1
申请日:
2011.07.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
