A method for treating hypertriglyceridemia with a composition containing wedelolactone, luteolin, and apigenin. Also provided is a method for reducing the risk of developing hypertriglyceridemia by administering the composition to a subject at risk thereof. The composition can be an extract of Wedelia chinensis.一種以一組成物來治療高三酸甘油脂症的方法,該組成物包含蟛蜞菊內酯、葉黃酮及洋元荽黃素。亦提供一種降低發展高三酸甘油脂症之風險的方法,該方法係藉由將該組成物投予至處於該風險的受試者。該組成物可為蟛蜞菊之一萃取物。