Dimitri N. Theofilopoulos;Thomas E. Ichim;Andy J. Kim;Samuel C. Wagner
发明人:
Samuel C. Wagner,Thomas E. Ichim,Dimitri N. Theofilopoulos,Andy J. Kim
申请号：
US14807766
公开号：
US20160022761A1
申请日:
2015.07.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are compositions of peptides derived from the High Mobility Group Box 1 (HMGB1) protein that are useful in suppressing inhibitory activity of T regulatory cells in conditions of cancer and virus infections. Specifically, this application provides means of derepressing immunity in a state of immune suppression through significantly decreasing the number and/or activity of T regulatory cells.
