A modified release formulation of a proton pump inhibitor comprising of two discreet portions or compositions wherein the release of the active ingredient is controlled, which releases the active ingredient for an extended period of time such that 10% - 35% of the label claim of the active is released in the pH range of no less than 5.0 to no more than 6.0 and the remaining 90% - 65% of the label claim of the active drug substance in the pH range of no less than 6.0 to no more than 7.5 using pH-independently soluble and/or swellable polymer or polymer mixture to control the release in the pH range of no less than 5.0 to no more than 6.0 and pH-dependently soluble and/or swellable polymer or polymer mixture to control the release in the pH range of no less than 6.0 to no more than 7.5.
