John Knopf,Ravindra Kumar,Robert S. Pearsall,Matthew L. Sherman
申请号：
US14046195
公开号：
US20140193425A1
申请日:
2013.10.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods for evaluating responsiveness of a subject having cancer to treatment with an activin receptor-like kinase 1 (ALK1) antagonist are provided. Methods for selecting a subject for treatment with an ALK1 antagonist based on the subject being identified as responsive to such treatment are also provided. Some of the diagnostic methods provided herein are based on detecting an ALK1 agonist, e.g., an ALK1 ligand such as BMP9 or BMP10, in a sample obtained from the subject. Diagnostic reagents and kits for determining whether a subject is responsive to treatment with an ALK1 antagonist are also provided.
