연세대학교 산학협력단; YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
HAAM, SEUNG JOO,함승주,HUH, YONG MIN,허용민,KIM, HYUN OUK,김현욱,CHOI, JI HYE,최지혜,JANG, EUN JI,장은지,KANG, BYUNG HOON,강병훈,NOH, IL KOO,노일구,SONG, SEUNG WON,송승원,HAN, SEUNG MIN,한승민,HAAM, SEUNG JOOKR,HUH, YONG MINKR,KIM, HYUN OUKKR,CHOI, JI HYEKR,JANG, EUN JIKR,KANG, BYUNG HOONKR,NOH, IL KOOKR,SONG, SEUNG WONKR,HAN, SEUNG MINKR
申请号：
KR1020140078112
公开号：
KR1020160000935A
申请日:
2014.06.25
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a bioenvironment-sensitive nanoparticle comprising a polymer with a complementary charge. The present invention further relates to a production method thereof and a pharmaceutical use thereof. According to the present invention, the nanoparticle stays in a stable state in an environment outside a cell. Thus, efficient and stable delivery of a target molecule such as a drug is possible even with a small quantity. Furthermore, the nanoparticle of the present invention tends to be specific in the cancer cell environment. Thus, the cancer cell-specific diagnosis or treatment is possible as well.본 발명은 상보적인 전하를 가지는 고분자를 포함하는 생체환경 감응형 나노입자, 이의 제조방법 및 이의 약제학적 용도에 관한 것이다. 본 발명에 따른, 나노입자는 세포 밖 환경에서 안정하기 때문에, 적은 양으로도, 약물 등의 목적 물질을 안정하고 효율적으로 전달할 수 있다.또한, 본 발명의 나노입자는 암세포의 환경에 특이적이기 때문에, 암세포 선택적 진단 또는 치료가 가능하다.
