MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
SCHIEMANN, KAI,FINSINGER, DIRK,AMENDT, CHRISTIANE,ZENKE, FRANK
申请号：
CA2681256
公开号：
CA2681256C
申请日:
2008.02.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of the formula I(see formula I)whereinR1 denotes H, A, Hal, SA, (CH2)p CN, SCN, (CF2)p CF3, SF5, OA, O(CF2)p CF3,S(CF2)p CF3, NR2, NRCOR, NRSO2R, NR(CH2)p NR2, CONR(CH2)p NR2,SO2NR(CH2)p NR2, CONR2, SO2NR2, COOR,R2 denotes H, Hal,R3 denotes H, A,A denotes alkyl or cycloalkyl,R4 denotes aryl or heteroaryl,Y denotes H, A, Hal, OR,R denotes H, A, (CH2)p O(CH2)p R3, (CH2)p NA(CH2)p R3,W denotes CH2, C=O, C=S,Q1 denotes NR, O, S,Z denotes -SO-, (see formula II, see formula III, see formula IV,see formula V, see formula VI, see formula VII, see formula VIII, see formulaIX,see formula X, see formula XI, see formula XII, see formula XIII, )Q2 denotes NR, S, O or a single bond,R5 denotes H, (CY2)p NR2, (CY2)p OR, (CY2)p SR, (see formula XIV)(CY2)p Q1COQ1R, (CY2)p COOR, Hal,Hal denotes F, Br, CI,n denotes 1, 2, 3, 4,m denotes 0, 1, 2,p denotes 0, 1, 2, 3, 4, 5, 6, 7, 8ands denotes 0, 1, 2,and their use for the treatment of tumours.
