Eunjoon Kim,Changwon Kang,Won Mah,Hyejung Won,Eun-Kyoung Hahm,Eunjin Kim
申请号：
US13446789
公开号：
US08552253B2
申请日:
2012.04.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided is a method of using any mammal except humans, in particular, a mammal as an attention deficit hyperactivity disorder model, wherein genes of G protein-coupled receptor kinase interacting protein 1 (GIT1) as a neuronal synapse protein in the brain are knocked out from the mammal. In addition, disclosed is analysis of GIT1 knock-out mice in aspects of molecular biology, cellular biology, electrical biology and animal behavior and, more particularly, a screening method of novel drug, wherein excessive behavior as an attention deficit hyperactive disorder as well as recovery of theta wave in the frontal lobe are observed by administering a candidate material of the drug, thereby inducing recovery of the attention deficit hyperactivity disorder.
