Sumit MADAN,Anuj Kumar FANDA,Pankaj Prabhakar AMRUTKAR,Rajesh RAO,Jitendra KAWADKAR,Vasu Kumar KAKUMANU,Ravi KOCHHAR,Romi Barat SINGH,Dileep JAMI,Lokesh GARG,Sandipan ROY
申请号：
US15822076
公开号：
US20180071240A1
申请日:
2017.11.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a modified-release, once-daily, oral pharmaceutical composition comprising isotretinoin and a process for its preparation. In some embodiments, the disclosure is directed to a modified-release, oral pharmaceutical composition comprising isotretinoin or a pharmaceutically acceptable salt, ester or a derivative thereof； and a release modifying agent, wherein the composition is suitable for once daily administration. In some embodiments, the disclosure is directed to a modified-release, oral pharmaceutical composition comprising isotretinoin, wherein the composition comprises an immediate-release component； and a modified-release component comprising a release modifying agent, and wherein the composition is suitable for once daily administration.
