A dose control mechanism (510, 610) for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger (514, 614) and a longitudinally extending channel (520D, 620D) of a housing (520, 620). The engaging screw thread arrangement includes at least one thread segment (514B, 614B) and a pitch guide (520C, 620C) including a variable pitch thread. At least a portion of the longitudinally extending channel (520D, 620D) of the housing (520, 620) including one of the pitch guide (520C, 620C) and the at least one thread segment (514B, 614B), and the plunger (514, 614) includes the other of the pitch guide (520C, 620C) and the at least one thread segment (514B, 614B). The plunger (514, 614) resides at least partially within the housing (520, 620) with the at least one thread segment (514B, 614B) engaged with the pitch guide (520C, 620C). An accurate dose drug delivery syringe (500, 600) includes such a dose control mechanism (510, 610), a barrel (540, 640), a plunger seal (536, 636), and a barrel adapter assembly (450) having a barrel tip (452) and a needle (454). The syringe (500, 600) may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.La présente invention décrit un mécanisme de contrôle de dose (510, 610) destiné à une seringue comprenant un montage de filetage de vis de mise en prise entre une surface extérieure d'un piston (514, 614) et un canal s'étendant longitudinalement (520D, 620D) d'un logement (520, 620). Le montage de filetage de vis de mise en prise comprend au moins un segment de filetage (514B, 614B) et un guide de pas (520C, 620C) comprenant un filetage à pas variable. Au moins une partie du canal s'étendant longitudinalement (520D, 620D) du logement (520, 620) comprenant l'un du guide de pas (520C, 620C) et dudit segment de fi
