DEBIOPHARM INTERNATIONAL SA;AURIGENE DISCOVERY TECHNOLOGIES LIMITED
发明人:
MC ALLISTER, ANDRÈS,MURONE, MAXIMILIEN,SENGUPTA, SAUMITRA,SHETTY, SHANKAR JAYARAM
申请号：
ES11709484
公开号：
ES2470190T3
申请日:
2011.02.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) having the structure: ** Formula ** where R 1 is H, aryl, substituted aryl, alkyl, substituted alkyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl or substituted heterocyclyl alkyl, X is CH2 or C>； = O R2 is H, (C1-C6) alkyl, halogen, CF3 or O (C1-C6) alkyl and is -NHCO-, -CONH-, -NHSO2-, -NH-, -NCH3-CO -, -NHCH2-, O, -NHCONH- or -NHCOCH2- R3 is alkyl, substituted alkyl, aryl or substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl or heterocycloalkyl wherein the term "alkyl" refers to aliphatic groups saturated, including straight chain alkyl groups, branched chain alkyl groups, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups and cycloalkyl substituted alkyl groups； the term "cycloalkyl" refers to a saturated or partially saturated, monocyclic or fused carbocycle or polycyclic spiro； The term "heterocycloalkyl" or "heterocyclyl" refers to a non-aromatic, partially unsaturated or fully saturated, 3-membered ring system that includes individual rings of 3 to 8 atoms and bi- or tri-cyclic ring systems that can include six-membered aromatic aryl or heteroaryl rings fused to a non-aromatic ring； The term "substituted" refers to the substitution with one or more or any combination of the following substituents: hydroxy, halogen, carboxyl, cyano, nitro, oxo (>； = O), thio (>； = S), substituted or non-substituted alkyl substituted, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted haloalkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl alkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substitut
