PROBLEM TO BE SOLVED: To provide a dosage form to treat gastrointestinal disorder containing a PPI for alleviating nocturnal breakthrough events where the secretory activity of the proton pumps return in patients on PPI (proton pump inhibitor) therapy.SOLUTION: The first and second doses of PPI can be administered in a single oral dosage form that can be taken once a day, the first and second doses are released in continuous form, each of the first and second doses comprises PPI in an amount sufficient to raise the plasma levels of the PPI to a threshold level of at least 100 ng/ml, and the second dose comprises PPI at least 10% more than the first dose.【課題】胃腸障害を治療する方法であって、ＰＰＩ（プロトンポンプ阻害剤）治療中の患者においてプロトンポンプの分泌活性が元に戻るという夜間抑制減弱（ｎｏｃｔｕｒｎａｌ ｂｒｅａｋｔｈｒｏｕｇｈ）事象を軽減するための、ＰＰＩを含む剤形の提供。【解決手段】ＰＰＩの初回および２回目の用量が、１日１回の服用が可能な１回分の経口投与剤形で投与されることができ、ＰＰＩの初回および２回目の用量は持続的な様式で放出され、初回および２回目の用量の各々は、ＰＰＩの血漿中レベルを少なくとも１００ｎｇ／ｍｌの閾値濃度に上昇させるのに十分なＰＰＩ量を含み、２回目の用量が初回の用量よりもＰＰＩを少なくとも１０％多く含む剤形。【選択図】図１
