The invention relates to a composition for the simultaneous disinfection and decontamination of bodies contaminated by CTAs such as bacteria, yeasts, mould spores, viruses or others, and NCTAs such as prions. According to the invention, the composition includes a hydrogen peroxide solution and an aqueous solution of copper or a derivative thereof such as copper salts, and at least one anionic salified surfactant compound inhibiting the decomposition of hydrogen peroxide in the presence of copper. Said composition can be prepared extemporaneously from a mixture of an aqueous copper solution and of an aqueous hydrogen peroxide solution. The invention further relates to an aqueous copper solution and to an aqueous hydrogen peroxide solution to be mixed together.