Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
The University of Iowa Research Foundation;AlderBio Holdings LLC
发明人:
Russo, Andrew F.,Kaiser, Eric A.,Recober, Ana,Kuburas, Adisa,Raddant, Ann C.,Kovacevich, Brian Robert,Latham, John A.,Smith, Jeffrey T.L.,Garcia-Martinez, Leon F.
申请号：
AU2012258980
公开号：
AU2012258980B8
申请日:
2012.05.21
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like. The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the V
