The method of manufacturing kinesio brace includes steps of: preparing an elastic body which is tube-shaped to have a first face inside and a second face outside, the elastic body defining an axial direction； inserting an inner mold into the elastic body so that the first face faces to the inner mold； placing the inner mold with the elastic body into an outer mold and closing the outer mold, the outer mold being formed with at least one groove on an inner surface thereof； injecting a plastic material into the groove to shape into a plastic layer which is engaged with the second face of the elastic body； removing the outer mold and the inner mold from the elastic body, reversing the elastic body to make the second face and the plastic layer face inward to provide a kinesio brace.
