YICHANG HUMANWELL PHARMACEUTICAL CO., LTD.;WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
发明人:
ZHANG, WENSHENG,YANG, JUN,LIU, JIN
申请号：
CA2801818
公开号：
CA2801818C
申请日:
2010.10.13
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Phosphoric acid ester compound of hydroxy acid substituted phenyl ester, synthesis method and medical use thereof. The title compound is shown in formula (I), in which Y= C1-4 straight-chain carbon chain and M1 and/or M2 = H, alkali metal ion, protonated amine, or protonated amino acid. The compound has good water solubility and high stability of its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of in-vivo enzymes, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compounds can be used for sedation, hypnosis, and/or anesthesia.
