A fusion spine internal fixation screw comprises a screw cap section (20) and a bone joint section (10) connected with the screw cap section (20), wherein the bone joint section (10) comprises a solid part (12) and a porous fusion part (11) fixedly arranged on the surface of the solid part (12) and the porous fusion part (11) is provided with a porous structure inosculated with spine sclerotins. The porous fusion part (11) of the bone joint section (10) of the fusion spine internal fixation screw is of a porous structure, which can promote bone cells to grow therein to fuse sclerotins with the screw after the fusion spine internal fixation screw is implanted into the sclerotins, so as to finally form a bone fusion state, which can effectively prevent the fusion spine internal fixation screw from being loosened or unscrewed in a long term.