BLEIN STANISLAS,ATTINGER ANTOINE,BACK JONATHAN ALBERT,LISSILAA RAMI,HOU SAMUEL
申请号：
NZ61984912
公开号：
NZ619849A
申请日:
2012.07.09
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an antagonist antibody or fragment thereof that binds to human OX40 comprising a heavy chain CDR1 comprising the amino acid sequence of GFSLSTSGMG, and a heavy chain CDR2 comprising the amino acid sequence of IWWDDDK, and a heavy chain CDR3 comprising the amino acid sequence of ARIDWDGFAY； and comprising a light chain CDR1 comprising the amino acid sequence of SSVSY, and a light chain CDR2 comprising the amino acid sequence of ATS and a light chain CDR3 comprising the amino acid sequence of QQWSSNPWT. Also disclosed is the use of the above-described antibody or fragment thereof in the manufacture of a medicament for treating an OX40 mediated disorder in a subject.
