In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.在一個態樣中，提供特異性結合至人類τ蛋白之抗體。在一些實施例中，抗τ抗體識別在全長人類τ蛋白之殘基111-125內的抗原決定基、在全長人類τ蛋白之殘基251-270及/或殘基346-360內的抗原決定基或在全長人類τ蛋白之殘基186-205內的抗原決定基。在一些實施例中，抗τ抗體特異性結合至磷酸化人類τ蛋白、未磷酸化之人類τ蛋白及/或人類τ蛋白之多種剪接同功型。本文所揭示之抗τ抗體亦可包括一種或兩種經修飾Fc多肽。
