Trustees of Dartmouth College;King's College London
发明人:
Randolph J. Noelle,Sabrina Ceeraz,Isabelle LeMercier,Elizabeth Nowak,Janet Lines
申请号：
US13925034
公开号：
US20140220012A1
申请日:
2013.06.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.
