The invention provides a method for diagnosing likelihood of a renal disease in a subject suspected of the renal disease, comprising: measuring a value of delta O-18 (δ18O) and/or delta H-2 (δ2H) in a biological sample of the subject suspected of the renal disease, comparing the measured value of delta O-18 and/or delta H-2 with a reference value of delta O-18 and/or delta H-2 obtained from a subject without a renal disease and diagnosing the likelihood of a renal disease based on the comparison of the measured value of delta O-18 and/or delta H-2 with the reference value of delta O-18 and/or delta H-2, wherein the likelihood of a renal disease is diagnosed when the value of delta O-18 and/or delta H-2 in the biological sample of the subject suspected of the renal disease is lower than the reference value of delta O-18 and/or delta H-2 obtained from a subject without a renal disease.. Also provided is a kit for carrying out the method of the invention.本發明提供一種在疑似腎臟疾病或腫瘤疾病的個體診斷腎臟疾病或腫瘤疾病可能性的方法,包括測定疑似腎臟疾病或腫瘤疾病的個體的生物樣品中delta O-18(δ18O)和/或delta H-2(δ2H)的值,比較該測定的delta O-18(δ18O)和/或delta H-2(δ2H)值與沒有腎臟疾病或腫瘤疾病的個體的delta O-18(δ18O)和/或delta H-2(δ2H)的參考值,基於該測定的delta O-18(δ18O)和/或delta H-2(δ2H)值與delta O-18(δ18O)和/或delta H-2(δ2H)的參考值的比較診斷腎臟疾病或腫瘤疾病的可能性;其中當疑似腎臟疾病或腫瘤疾病的個體的生物樣品中delta O-18(δ18O)和/或delta H-2δ2H)的值低於沒有腎臟疾病或腫瘤疾病的個體的delta O-18(δ18O)和/或delta H-2(δ2H)的參考值時,則診斷為有腎臟疾病或腫瘤疾病的可能性。本發明亦提供一種實施本發明方法的套組。
