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PHARMACEUTICAL COMPOSITION CONTAINING OLMESARTAN MEDOXOMIL IN AN AMORPHOUS FORM PREPAED BY HOTMELT EXTRUSION
专利权人:
发明人:
VAVIA PRADEEP RATILAL,JADHAV PANKAJ HANUMANTRAO
申请号:
IN2252/MUM/2015
公开号:
IN2015MU02252A
申请日:
2015.12.11
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
Abstract The present invention provides compositions comprising amorphous form of Olmesartan Medoxomil and methods of manufacture. The amorphous form was made by the process of hot melt extrusion or other thermal means. Formulated amorphous dispersions shows enhanced solubility, dissolution rate and bioavailability. The resultant homogeneous amorphous drug embedded polymeric matrix can be successfully transformed into suitable oral pharmaceutical dosage from like pellets, granules, immediate and modified release tablets, oral fast dissolving systems.
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